The effect of treatment with sacubitril-valsartan was not modified by region (interaction P>0.05). Rates of the primary composite end point of total hospitalizations for HF and death from cardiovascular causes were lower in patients from Central Europe (9 per 100 patient-years) and highest in patients from North America (28 per 100 patient-years), which was primarily driven by a greater number of total hospitalizations for HF. Results: Regional differences in patient characteristics and comorbidities were observed: patients from Western Europe were oldest (mean 75☗ years) with the highest prevalence of atrial fibrillation/flutter (36%) Central/Eastern European patients were youngest (mean 71☘ years) with the highest prevalence of coronary artery disease (50%) North American patients had the highest prevalence of obesity (65%) and diabetes (49%) Latin American patients were younger (73☙ years) and had a high prevalence of obesity (53%) and Asia-Pacific patients had a high prevalence of diabetes (44%), despite a low prevalence of obesity (26%). Methods: We studied differences in clinical characteristics, outcomes, and treatment effects of sacubitril/valsartan in 4796 patients with HFpEF from the PARAGON-HF trial, grouped according to geographic region.
Paragon trial trial#
We investigated these differences in the PARAGON-HF trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin Receptor Blocker Global Outcomes in HFpEF), the largest and most inclusive global HFpEF trial.
Background: Heart failure with preserved ejection fraction (HFpEF) is a global public health problem with important regional differences.
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